Looney Tunes Wile E Coyote ~ Coyote repeatedly attempts to catch and eat the Road Runner, but is never successful. Coyote, instead of his species' animal instincts, uses absurdly complex contraptions and elaborate plans to pursue his prey, which always comically backfire with Wile normally getting injured by the slapstick humor. He is generally silent in the Coyote-Road Runner cartoons. TV Guide included Wile E. Coyote in their list of The 60 Nastiest Villains of All Time.
Felix the Cat ==He has literally been around since the silent film era of the 20s. Now that is friggin old. He was in the comics and on merchandise in the 20s. There was even a song named after him. But when sound came into cartoons in the late 20s, he started dying away and gave way to Mickey Mouse, etc. In 1953 they put him to sound and put him back on TV and gave him a bag of tricks, which all the villains tried to steal.